Dred Scott was born into slavery in Virginia around 1800. He was owned by Peter Blow and his wife, Elizabeth Taylor Blow, both Virginians. Dred grew up, probably in slave quarters, on the Blow property in Southampton County. In 1818, when Dred Scott was a young man, he moved with the Blows, their six children, and several other slaves to a cotton plantation in Alabama. For the next twelve years, Scott worked for the Blows. Two more children, sons Taylor and William, were born to the Blows in Alabama.

In 1830, Scott moved again when the Blow family gave up farming and relocated to St. Louis, Missouri. Here they ran a boardinghouse called the Jefferson Hotel. Elizabeth Blow died in 1831 with Peter following in 1832. Before he died, however, Peter Blow sold Dred Scott to Dr. John Emerson, an assistant surgeon in the army stationed at Jefferson Barracks. Scott became Dr. Emerson's body servant or valet.

On December 1, 1833, Dred Scott traveled with Dr. Emerson to Fort Armstrong, at Rock Island, in Illinois. For the first time, Scott was living in "free" territory. For the next three years, he lived and attended to Dr. Emerson's needs at Fort Armstrong. When the fort was abandoned on May 4, 1836, Dr. Emerson was transferred to Fort Snelling on the upper Mississippi in the Wisconsin Territory, now Minnesota. Scott traveled up the Mississippi River, even farther north.

At Fort Snelling, Dred Scott met Harriet Robinson, a slave from Virginia who was about fifteen years younger than him. In either 1836 or 1837, they were married by Harriet's owner, Major Lawrence Taliaferro, an Indian agent and justice of the peace. Major Taliaferro was known for respecting the rights of Native Americans. He may have sold or transferred ownership of Harriet Robinson to Dr. Emerson and married her to Dred Scott so the couple could remain together.

For the next year, Dred Scott remained at Fort Snelling with his bride. By April 1838, however, he and Harriet—who was now pregnant—were sent south to Louisiana. Dr. Emerson had been transferred to Fort Jesup and had requested that Dred and Harriet Scott join him and his new wife, Eliza Irene Sanford. Soon after making the long trip to Louisiana, the Scotts were sent to St. Louis, and then back to Fort Snelling. Harriet gave birth to their daughter Eliza Scott in free waters on the steamer Gipsey. Dred Scott remained at Fort Snelling for another two years, working for Dr. Emerson and living with his wife and infant daughter.

During the summer of 1840, Dred Scott left Fort Snelling, never to return. Dr. Emerson had been transferred to Florida to provide medical assistance to soldiers in the Seminole War. Scott and his family were sent to St. Louis where they were hired out to work for various people while the Emersons collected their wages. Dred and Harriet had another daughter, Lizzie Scott, during this time.

In 1843, Dr. Emerson died suddenly. Though neither Dred nor Harriet appeared in Dr. Emerson's will, Irene Emerson considered them her property. Mrs. Emerson moved in with her proslavery father, Alexander Sanford, on his plantation near St. Louis. Her brother, John F.A. Sanford, a successful businessman, handled many of her affairs. For the next three years, Dred and Harriet Scott worked for other people while Mrs. Emerson collected their wages.

The practice of hiring out slaves may have been convenient for the owner, but it was not a positive experience for most slaves. On April 6, 1846, Dred and Harriet Scott each filed separate petitions in the Circuit Court of St. Louis to gain their freedom from Irene Emerson. Francis Murdock was their lawyer. Unable to read or write, Scott perhaps relied on advice from the Blow family, with whom he had renewed contact since returning to St. Louis. Additionally, Harriet Scott knew John R. Anderson, the minister of the Second African Baptist Church, who had helped other slaves file petitions for their freedom in Missouri courts.

It was not uncommon for slaves to sue for their freedom if they had lived in free states for a period of time. Dred Scott had lived in free territory for the past decade, so it seemed that his case would have a positive outcome. With the financial and legal help of the Blow brothers, Henry and Taylor, and their friends, Dred and Harriet's cases came to trial on June 30, 1847. Unfortunately, their cases were dismissed on a technicality. Their lawyer moved for a new trial.

Irene Emerson quickly made arrangements for the Scotts to be put under the charge of the St. Louis County sheriff. For almost ten years, from March 17, 1848, until March 18, 1857, Dred Scott and his family would be in the sheriff's custody. The sheriff was responsible for hiring out the Scotts and collecting and keeping their wages until the freedom suit was resolved.

Dred Scott worked another two years as a hired out slave with no income before his case came to trial again. His case and Harriet's were delayed due to heavy court schedules, a devastating fire in St. Louis in 1849, and a subsequent outbreak of cholera. Finally, on January 12, 1850, the case was heard, and the jury ruled in favor of the Scotts. Dred Scott and his family were free.

Unfortunately, Dred Scott's freedom was short lived. Mrs. Emerson would not accept the court's decision. With the assistance of her brother, Mrs. Emerson appealed her case to the Missouri Supreme Court. Before it came to trial, however, a decision was made to combine Harriet's case with Dred's. On February 12, 1850, the case was renamed Dred Scott v. Irene Emerson, and its outcome would apply to Harriet. Again, there was a lengthy wait before the new case went to trial.

In the meantime, Mrs. Emerson left St. Louis, moved to Springfield, Massachusetts, and married Dr. Calvin Clifford Chaffee, an antislavery congressman. Dr. Chaffee was unaware that his new wife owned slaves and that she was resisting their plea for freedom. On March 22, 1852, the Missouri Supreme Court reversed the earlier ruling. Dred Scott was still a slave, despite his years living in free states. The "once free, always free" statute in earlier legislation was denied by proslavery judges. In this decision, the highest court in Missouri upheld the rights of slave owners over the rights of slaves. Tensions and outbursts over the issue of slavery were now regular occurrences throughout the nation.

Dred and Harriet Scott did not give up. With the continued help of new lawyers, the Blow family, and other supporters, Dred Scott's case moved through the Missouri courts to the highest court in the nation. At this point, John Sanford, who lived in New York, claimed ownership of the Scotts. The Scott's new lawyer, Roswell Field, appealed the decision and added Scott's daughters to the case. Eventually, Field arranged for the case to go before the U.S. Supreme Court. He convinced Montgomery Blair to argue for the Scotts in what became the famous Dred Scott v. Sanford case.

On March 6, 1857, Dred Scott finally received a decision about his suit for freedom. Chief Justice Roger B. Taney ruled that Scott, because of his race, was not a citizen of the United States. He had no right to bring suit in a federal court. He had never been free while living in "free states," and the Congress had no authority to prohibit slavery. The entire Scott family was to remain enslaved.

Shortly after Judge Taney's verdict, John Sanford died, and Dr. and Mrs. Chaffee transferred ownership of Scott and his family to Taylor Blow in St. Louis. Dr. Chaffee was eager to free his wife's slaves because he believed that slavery was wrong. Mrs. Chaffee, however, would only transfer ownership if she could collect the wages that had been held by the sheriff for the past eight years. The total amounted to about $750.

On May 26, 1857, Dred and Harriet Scott appeared in the Circuit Court of St. Louis for the last time. Taylor Blow emancipated them with papers drawn up by Arba Nelson Crane and presented to Judge Alexander Hamilton, the judge who had originally heard the case. Afterwards, Dred and Harriet Scott were interviewed, and engravings of them appeared in the June 27, 1857, edition of Frank Leslie's Illustrated Newspaper.

For the next year, Dred Scott worked as a porter at Barnum's Hotel in St. Louis. He also delivered the laundry that Harriet took in as a free laundress. Scott was known by many people because of his famous freedom suit. His daguerreotype was taken during this year. Sadly, Scott became sick with tuberculosis and died on September 17, 1858, just a little more than a year after gaining his freedom.

Taylor Blow buried Dred Scott in the Wesleyan Cemetery at Grand and Laclede avenues. Later, because the cemetery had been abandoned, Blow bought a better resting place for Scott. On November 27, 1867, Blow purchased Lot 177 in Section 1 in Calvary Cemetery and had Scott reburied there. This action showed Blow's strong regard for the man he'd known since infancy.