Susan Elizabeth Blow was born in St. Louis, Missouri, on June 7, 1843. She was the oldest of six children born to Henry Taylor Blow and Minerva Grimsley Blow. Susan’s family was well off. Her father was a wealthy businessman who made his money in the lead industry. He became a leader in St. Louis business and Missouri politics.

Susan lived in a home on the Mississippi riverfront until she was six years old. In 1849, a great fire burned the riverfront and downtown St. Louis. It destroyed many buildings, including Susan’s home. Then a deadly cholera epidemic swept through the city. It killed about seven thousand people and caused many families to resettle in outlying areas. Henry Taylor Blow moved his family to Carondelet, a French settlement five miles downriver from St. Louis.

Susan had a very comfortable lifestyle because of her father’s wealth and position in society. She also received a fine education, unlike many children of the time who spent their days working on farms or in factories. Susan’s father knew that she was very intelligent. In a letter dated 1857 he wrote, “Sue must have the best advantage in education.”

Susan had lessons with governesses at home and also attended a private school in New Orleans, Louisiana. She liked sharing what she learned with her younger brothers and sisters. In 1859, when she was sixteen, Susan attended a private school in New York City. Her education there was cut short by the Civil War. In 1861, the school shut down and Susan returned to Missouri. The Blows were pro-Union and antislavery.

During the Civil War, Susan Blow studied on her own using the family library. She wanted to learn as much as she could. Some people thought she was “too bookish.” But Susan didn’t let anything stop her from studying or learning more. She even joined a group of thinkers in St. Louis so she could talk with others about her ideas.

Four years after the Civil War, Henry Taylor Blow was appointed ambassador to Brazil. Susan Blow went with her father and worked as his secretary for fifteen months. Afterwards, she traveled to Germany. There she had an experience that gave the rest of her life direction. She observed classrooms inspired by the work of Friedrich Froebel, an important leader in early education. In these "kindergarten" classrooms, Blow noticed that young children learn important language, math, and science skills by playing with objects such as balls and blocks. She decided that children in America should have this kind of instruction, too.

Back in America, Susan Blow studied and learned everything she could about teaching kindergarten. She talked with educators about creating a kindergarten program in America. Henry Taylor Blow asked Dr. William Torrey Harris, the superintendent of St. Louis Public Schools, to open an experimental kindergarten. Susan Blow offered to direct it if Dr. Harris would provide a room and a paid teacher.

In September 1873, Susan Blow opened the first public kindergarten at the Des Peres School in Carondelet. While most classrooms were plain, Blow’s kindergarten classroom was bright and cheerful. It had low tables and short benches just right for small children. The room contained many plants, books, and toys for children to use during work and play. Students learned about color, shapes, and fractions by using simple objects like balls and blocks. They also learned about keeping themselves clean, eating well, and getting regular exercise.